Flash Survey on SARS-CoV-2 Infections in Pediatric Patients on anti-Cancer Treatment
Identifieur interne : 000630 ( Main/Exploration ); précédent : 000629; suivant : 000631Flash Survey on SARS-CoV-2 Infections in Pediatric Patients on anti-Cancer Treatment
Auteurs : Ondrej Hrusak ; Tomas Kalina ; Joshua Wolf [États-Unis] ; Adriana Balduzzi [Italie] ; Massimo Provenzi [Italie] ; Carmelo Rizzari ; Susana Rives [Espagne] ; María Del Pozo Carlavilla [Espagne] ; Maria Eli Valerio Alonso [Espagne] ; Nerea Domínguez Pinilla [Espagne] ; Jean-Pierre Bourquin [Suisse] ; Kjeld Schmiegelow [Danemark] ; Andishe Attarbaschi [Autriche] ; Pernilla Grillner [Suède] ; Karin Mellgren [Suède] ; J. Ten Bosch Van Der Werff [Belgique] ; Rob Pieters [Pays-Bas] ; Triantafyllia Brozou ; Arndt Borkhardt ; Gabriele Escherich [Allemagne] ; Melchior Lauten [Allemagne] ; Martin Stanulla [Allemagne] ; Owen Smith [Irlande (pays)] ; Allen Eng Juh Yeoh [Singapour] ; Sarah Elitzur ; Ajay Vora [Royaume-Uni] ; Chi-Kong Li [Hong Kong] ; Hany Ariffin [Malaisie] ; Alexandra Kolenova [Slovaquie] ; Luciano Dallapozza [Australie] ; Roula Farah [Liban] ; Jelena Lazic [Serbie] ; Atsushi Manabe [Japon] ; Jan Styczynski [Pologne] ; Gabor Kovacs [Hongrie] ; Gabor Ottoffy [Hongrie] ; Marisa Felice [Argentine] ; Barbara Buldini [Italie] ; Valentino Conter [Italie] ; Jan Stary ; Martin Schrappe [Allemagne]Source :
- European Journal of Cancer [ 0959-8049 ] ; 2020.
Abstract
Since the beginning of COVID-19 pandemics, it is known that the severe course of the disease occurs mostly among elderly, whereas it is rare among children and young adults. Comorbidities, in particular diabetes and hypertension, clearly associated with age, besides obesity and smoke are strongly associated with the need of intensive treatment and a dismal outcome. A weaker immunity of the elderly has been proposed as a possible explanation of this uneven age distribution. Along the same line, anecdotal information from Wuhan, China mentioned a severe course of COVID-19 in a child treated for leukemia.
We made a flash survey on COVID19 incidence and severity among children on anticancer treatment. Respondents were asked by email to fill in a short web based survey.
We received reports from 25 countries, where approximately 10,000 patients at risk are followed. At the time of the survey, over 200 of these children were tested, nine of whom were positive for COVID-19. Eight of the nine cases had asymptomatic to mild disease and one was just diagnosed with COVID-19. We also discuss preventive measures that are in place or should be taken as well as treatment options in immunocompromised children with COVID-19.
Thus, even children receiving anti-cancer chemotherapy may have a mild or asymptomatic course of COVID-19. While we should not underestimate the risk of developing a more severe course of COVID-19 than observed here, the intensity of preventive measures should not cause delays or obstructions in oncological treatment.
Url:
DOI: 10.1016/j.ejca.2020.03.021
PubMed: NONE
PubMed Central: 7141482
Affiliations:
- Allemagne, Argentine, Australie, Autriche, Belgique, Danemark, Espagne, Hong Kong, Hongrie, Irlande (pays), Italie, Japon, Liban, Malaisie, Pays-Bas, Pologne, Royaume-Uni, Serbie, Singapour, Slovaquie, Suisse, Suède, États-Unis
- Angleterre, Basse-Saxe, Grand Londres, Hambourg, Hongrie centrale, Hovedstaden, Schleswig-Holstein, Tennessee, Utrecht (province), Vienne (Autriche), Vénétie
- Budapest, Copenhague, Hambourg, Hanovre, Kiel, Londres, Padoue, Sha Tin, Utrecht, Vienne (Autriche)
- Université chinoise de Hong Kong, Université de Padoue, Université nationale de Singapour
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Susana" sort="Rives, Susana" uniqKey="Rives S" first="Susana" last="Rives">Susana Rives</name><affiliation wicri:level="1"><nlm:aff id="aff7">Hospital Sant Joan de Déu de Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Sant Joan de Déu de Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Del Pozo Carlavilla, Maria" sort="Del Pozo Carlavilla, Maria" uniqKey="Del Pozo Carlavilla M" first="María" last="Del Pozo Carlavilla">María Del Pozo Carlavilla</name><affiliation wicri:level="1"><nlm:aff id="aff8">Hospital General Universitario de Albacete, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital General Universitario de Albacete</wicri:regionArea></affiliation></author><author><name sortKey="Valerio Alonso, Maria Eli" sort="Valerio Alonso, Maria Eli" uniqKey="Valerio Alonso M" first="Maria Eli" last="Valerio Alonso">Maria Eli Valerio Alonso</name><affiliation wicri:level="1"><nlm:aff id="aff8">Hospital General Universitario de Albacete, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital General Universitario de Albacete</wicri:regionArea></affiliation></author><author><name sortKey="Dominguez Pinilla, Nerea" sort="Dominguez Pinilla, Nerea" uniqKey="Dominguez Pinilla N" first="Nerea" last="Domínguez Pinilla">Nerea Domínguez Pinilla</name><affiliation wicri:level="1"><nlm:aff id="aff9">Hospital Virgen de la Salud, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Virgen de la Salud</wicri:regionArea></affiliation></author><author><name sortKey="Bourquin, Jean Pierre" sort="Bourquin, Jean Pierre" uniqKey="Bourquin J" first="Jean-Pierre" last="Bourquin">Jean-Pierre Bourquin</name><affiliation wicri:level="1"><nlm:aff id="aff10">Department of Oncology and Children’s Research Center, University Children’s Hospital Zurich, Zurich, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Oncology and Children’s Research Center, University Children’s Hospital Zurich, Zurich</wicri:regionArea><wicri:noRegion>Zurich</wicri:noRegion></affiliation></author><author><name sortKey="Schmiegelow, Kjeld" sort="Schmiegelow, Kjeld" uniqKey="Schmiegelow K" first="Kjeld" last="Schmiegelow">Kjeld Schmiegelow</name><affiliation wicri:level="3"><nlm:aff id="aff11">Department of Peadiatrics and Adolescent Medicine, Rigshospitalet University Hospital, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Peadiatrics and Adolescent Medicine, Rigshospitalet University Hospital, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Attarbaschi, Andishe" sort="Attarbaschi, Andishe" uniqKey="Attarbaschi A" first="Andishe" last="Attarbaschi">Andishe Attarbaschi</name><affiliation wicri:level="3"><nlm:aff id="aff12">Department of Pediatric Hematology and Oncology, St. Anna Children's Hospital, Medical University of Vienna, Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Pediatric Hematology and Oncology, St. Anna Children's Hospital, Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Grillner, Pernilla" sort="Grillner, Pernilla" uniqKey="Grillner P" first="Pernilla" last="Grillner">Pernilla Grillner</name><affiliation wicri:level="1"><nlm:aff id="aff13">Pediatric Oncology, Karolinska University Hospital, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Pediatric Oncology, Karolinska University Hospital</wicri:regionArea><wicri:noRegion>Karolinska University Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Mellgren, Karin" sort="Mellgren, Karin" uniqKey="Mellgren K" first="Karin" last="Mellgren">Karin Mellgren</name><affiliation wicri:level="1"><nlm:aff id="aff14">Department of Pediatric Haematology and Oncology, Sahlgrenska University Hospital, Gothenberg, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Pediatric Haematology and Oncology, Sahlgrenska University Hospital, Gothenberg</wicri:regionArea><wicri:noRegion>Gothenberg</wicri:noRegion></affiliation></author><author><name sortKey="Ten Bosch Van Der Werff, J" sort="Ten Bosch Van Der Werff, J" uniqKey="Ten Bosch Van Der Werff J" first="J." last="Ten Bosch Van Der Werff">J. Ten Bosch Van Der Werff</name><affiliation wicri:level="1"><nlm:aff id="aff15">UZ Brussels, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>UZ Brussels</wicri:regionArea></affiliation></author><author><name sortKey="Pieters, Rob" sort="Pieters, Rob" uniqKey="Pieters R" first="Rob" last="Pieters">Rob Pieters</name><affiliation wicri:level="3"><nlm:aff id="aff16">Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Princess Maxima Center for Pediatric Oncology, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Brozou, Triantafyllia" sort="Brozou, Triantafyllia" uniqKey="Brozou T" first="Triantafyllia" last="Brozou">Triantafyllia Brozou</name><affiliation><nlm:aff id="aff17">Department of Pediatric Oncology Hematology and Clinical Immunology Heinrich Heine University Dusseldorf</nlm:aff></affiliation></author><author><name sortKey="Borkhardt, Arndt" sort="Borkhardt, Arndt" uniqKey="Borkhardt A" first="Arndt" last="Borkhardt">Arndt Borkhardt</name><affiliation><nlm:aff id="aff17">Department of Pediatric Oncology Hematology and Clinical Immunology Heinrich Heine University Dusseldorf</nlm:aff></affiliation></author><author><name sortKey="Escherich, Gabriele" sort="Escherich, Gabriele" uniqKey="Escherich G" first="Gabriele" last="Escherich">Gabriele Escherich</name><affiliation wicri:level="3"><nlm:aff id="aff18">Klinik für Pädiatrische Hämatologie und Onkologie Universtitätsklinikum Eppendorf, Hamburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinik für Pädiatrische Hämatologie und Onkologie Universtitätsklinikum Eppendorf, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Lauten, Melchior" sort="Lauten, Melchior" uniqKey="Lauten M" first="Melchior" last="Lauten">Melchior Lauten</name><affiliation wicri:level="1"><nlm:aff id="aff19">University Hospital Schleswig-Holstein, Campus Lübeck, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Hospital Schleswig-Holstein, Campus Lübeck</wicri:regionArea><wicri:noRegion>Campus Lübeck</wicri:noRegion><wicri:noRegion>Campus Lübeck</wicri:noRegion><wicri:noRegion>Campus Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Stanulla, Martin" sort="Stanulla, Martin" uniqKey="Stanulla M" first="Martin" last="Stanulla">Martin Stanulla</name><affiliation wicri:level="3"><nlm:aff id="aff20">Department of Pediatric Haematology and Oncology, Hannover Medical School, Hannover, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pediatric Haematology and Oncology, Hannover Medical School, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Smith, Owen" sort="Smith, Owen" uniqKey="Smith O" first="Owen" last="Smith">Owen Smith</name><affiliation wicri:level="1"><nlm:aff id="aff21">National Children’s Cancer Service, Children’s Health Ireland at Crumlin, Dublin, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>National Children’s Cancer Service, Children’s Health Ireland at Crumlin, Dublin</wicri:regionArea><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Juh Yeoh, Allen Eng" sort="Juh Yeoh, Allen Eng" uniqKey="Juh Yeoh A" first="Allen Eng" last="Juh Yeoh">Allen Eng Juh Yeoh</name><affiliation wicri:level="4"><nlm:aff id="aff22">Yong Loo Lin School of Medicine and Cancer Science Institute, National University of Singapore, and Viva-University Children's Cancer Centre, National University Hospital, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Yong Loo Lin School of Medicine and Cancer Science Institute, National University of Singapore, and Viva-University Children's Cancer Centre, National University Hospital</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Elitzur, Sarah" sort="Elitzur, Sarah" uniqKey="Elitzur S" first="Sarah" last="Elitzur">Sarah Elitzur</name><affiliation><nlm:aff id="aff23">Schneider Children's Medical Center of Israel</nlm:aff></affiliation></author><author><name sortKey="Vora, Ajay" sort="Vora, Ajay" uniqKey="Vora A" first="Ajay" last="Vora">Ajay Vora</name><affiliation wicri:level="3"><nlm:aff id="aff24">Great Ormond Street Hospital, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Great Ormond Street Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Li, Chi Kong" sort="Li, Chi Kong" uniqKey="Li C" first="Chi-Kong" last="Li">Chi-Kong Li</name><affiliation wicri:level="4"><nlm:aff id="aff25">Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong</nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Ariffin, Hany" sort="Ariffin, Hany" uniqKey="Ariffin H" first="Hany" last="Ariffin">Hany Ariffin</name><affiliation wicri:level="1"><nlm:aff id="aff26">University of Malaya Medical Centre, Kuala Lumpur, Malaysia</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>University of Malaya Medical Centre, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Kolenova, Alexandra" sort="Kolenova, Alexandra" uniqKey="Kolenova A" first="Alexandra" last="Kolenova">Alexandra Kolenova</name><affiliation wicri:level="1"><nlm:aff id="aff27">Department of Pediatric Hematology and Oncology, Comenius University, Bratislava, Slovakia</nlm:aff><country xml:lang="fr">Slovaquie</country><wicri:regionArea>Department of Pediatric Hematology and Oncology, Comenius University, Bratislava</wicri:regionArea><wicri:noRegion>Bratislava</wicri:noRegion></affiliation></author><author><name sortKey="Dallapozza, Luciano" sort="Dallapozza, Luciano" uniqKey="Dallapozza L" first="Luciano" last="Dallapozza">Luciano Dallapozza</name><affiliation wicri:level="1"><nlm:aff id="aff28">The Cancer Centre for Children, The Children's Hospital at Westmead, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>The Cancer Centre for Children, The Children's Hospital at Westmead</wicri:regionArea><wicri:noRegion>The Children's Hospital at Westmead</wicri:noRegion></affiliation></author><author><name sortKey="Farah, Roula" sort="Farah, Roula" uniqKey="Farah R" first="Roula" last="Farah">Roula Farah</name><affiliation wicri:level="1"><nlm:aff id="aff29">LAUMC-Rizk Hospital, Beirut, Lebanon</nlm:aff><country xml:lang="fr">Liban</country><wicri:regionArea>LAUMC-Rizk Hospital, Beirut</wicri:regionArea><wicri:noRegion>Beirut</wicri:noRegion></affiliation></author><author><name sortKey="Lazic, Jelena" sort="Lazic, Jelena" uniqKey="Lazic J" first="Jelena" last="Lazic">Jelena Lazic</name><affiliation wicri:level="1"><nlm:aff id="aff30">University Children`s Hospital, Belgrade, Serbia</nlm:aff><country xml:lang="fr">Serbie</country><wicri:regionArea>University Children`s Hospital, Belgrade</wicri:regionArea><wicri:noRegion>Belgrade</wicri:noRegion></affiliation></author><author><name sortKey="Manabe, Atsushi" sort="Manabe, Atsushi" uniqKey="Manabe A" first="Atsushi" last="Manabe">Atsushi Manabe</name><affiliation wicri:level="1"><nlm:aff id="aff31">Hokkaido University in Sapporo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Hokkaido University in Sapporo</wicri:regionArea></affiliation></author><author><name sortKey="Styczynski, Jan" sort="Styczynski, Jan" uniqKey="Styczynski J" first="Jan" last="Styczynski">Jan Styczynski</name><affiliation wicri:level="1"><nlm:aff id="aff32">Department of Pediatric Hematology and Oncology, Nicolaus Copernicus University, Bydgoszcz, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Pediatric Hematology and Oncology, Nicolaus Copernicus University, Bydgoszcz</wicri:regionArea><wicri:noRegion>Bydgoszcz</wicri:noRegion></affiliation></author><author><name sortKey="Kovacs, Gabor" sort="Kovacs, Gabor" uniqKey="Kovacs G" first="Gabor" last="Kovacs">Gabor Kovacs</name><affiliation wicri:level="3"><nlm:aff id="aff33">2nd Department of Paediatrics, Semmelweis University, Budapest, Hungary</nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>2nd Department of Paediatrics, Semmelweis University, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Ottoffy, Gabor" sort="Ottoffy, Gabor" uniqKey="Ottoffy G" first="Gabor" last="Ottoffy">Gabor Ottoffy</name><affiliation wicri:level="1"><nlm:aff id="aff34">Oncohematology Unit, Dep. of Ped., University of Pécs, Hungary</nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>Oncohematology Unit, Dep. of Ped., University of Pécs</wicri:regionArea><wicri:noRegion>University of Pécs</wicri:noRegion></affiliation></author><author><name sortKey="Felice, Marisa" sort="Felice, Marisa" uniqKey="Felice M" first="Marisa" last="Felice">Marisa Felice</name><affiliation wicri:level="1"><nlm:aff id="aff35">Hospital de Pediatría, "Prof. Dr. Juan P. Garrahan", Argentina</nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea>Hospital de Pediatría, "Prof. Dr. Juan P. Garrahan"</wicri:regionArea><wicri:noRegion>"Prof. Dr. Juan P. Garrahan"</wicri:noRegion></affiliation></author><author><name sortKey="Buldini, Barbara" sort="Buldini, Barbara" uniqKey="Buldini B" first="Barbara" last="Buldini">Barbara Buldini</name><affiliation wicri:level="4"><nlm:aff id="aff36">Onco Hematology Unit, Dept. Salute della Donna e del Bambino, Università degli Studi di Padova, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Onco Hematology Unit, Dept. Salute della Donna e del Bambino, Università degli Studi di Padova</wicri:regionArea><placeName><settlement type="city">Padoue</settlement><region type="region" nuts="2">Vénétie</region></placeName><orgName type="university">Université de Padoue</orgName></affiliation></author><author><name sortKey="Conter, Valentino" sort="Conter, Valentino" uniqKey="Conter V" first="Valentino" last="Conter">Valentino Conter</name><affiliation wicri:level="1"><nlm:aff id="aff4">Clinica Pediatrica Universita degli Studi di Milano Bicocca, Monza, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Clinica Pediatrica Universita degli Studi di Milano Bicocca, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation></author><author><name sortKey="Stary, Jan" sort="Stary, Jan" uniqKey="Stary J" first="Jan" last="Stary">Jan Stary</name><affiliation><nlm:aff id="aff2">Department of Pediatric Hematology, Charles University and Univ. Hospital Motol, Prague, Czechia</nlm:aff><wicri:noCountry code="subfield">Czechia</wicri:noCountry></affiliation></author><author><name sortKey="Schrappe, Martin" sort="Schrappe, Martin" uniqKey="Schrappe M" first="Martin" last="Schrappe">Martin Schrappe</name><affiliation wicri:level="3"><nlm:aff id="aff37">Childrens Hospital Medical Center Schleswig-Holstein, Kiel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Childrens Hospital Medical Center Schleswig-Holstein, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmc">7141482</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141482</idno><idno type="RBID">PMC:7141482</idno><idno type="doi">10.1016/j.ejca.2020.03.021</idno><idno type="pmid">NONE</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000F90</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000F90</idno><idno type="wicri:Area/Pmc/Curation">000F90</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000F90</idno><idno type="wicri:Area/Pmc/Checkpoint">000246</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000246</idno><idno type="wicri:Area/Ncbi/Merge">003E48</idno><idno type="wicri:Area/Ncbi/Curation">003E48</idno><idno type="wicri:Area/Ncbi/Checkpoint">003E48</idno><idno type="wicri:doubleKey">0959-8049:2020:Hrusak O:flash:survey:on</idno><idno type="wicri:Area/Main/Merge">000630</idno><idno type="wicri:Area/Main/Curation">000630</idno><idno type="wicri:Area/Main/Exploration">000630</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Flash Survey on SARS-CoV-2 Infections in Pediatric Patients on anti-Cancer Treatment</title><author><name sortKey="Hrusak, Ondrej" sort="Hrusak, Ondrej" uniqKey="Hrusak O" first="Ondrej" last="Hrusak">Ondrej Hrusak</name><affiliation><nlm:aff id="aff1">CLIP - Childhood Leukemia Investigation Prague</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Department of Pediatric Hematology, Charles University and Univ. Hospital Motol, Prague, Czechia</nlm:aff><wicri:noCountry code="subfield">Czechia</wicri:noCountry></affiliation></author><author><name sortKey="Kalina, Tomas" sort="Kalina, Tomas" uniqKey="Kalina T" first="Tomas" last="Kalina">Tomas Kalina</name><affiliation><nlm:aff id="aff1">CLIP - Childhood Leukemia Investigation Prague</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Department of Pediatric Hematology, Charles University and Univ. Hospital Motol, Prague, Czechia</nlm:aff><wicri:noCountry code="subfield">Czechia</wicri:noCountry></affiliation></author><author><name sortKey="Wolf, Joshua" sort="Wolf, Joshua" uniqKey="Wolf J" first="Joshua" last="Wolf">Joshua Wolf</name><affiliation wicri:level="2"><nlm:aff id="aff3">Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Balduzzi, Adriana" sort="Balduzzi, Adriana" uniqKey="Balduzzi A" first="Adriana" last="Balduzzi">Adriana Balduzzi</name><affiliation wicri:level="1"><nlm:aff id="aff4">Clinica Pediatrica Universita degli Studi di Milano Bicocca, Monza, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Clinica Pediatrica Universita degli Studi di Milano Bicocca, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation></author><author><name sortKey="Provenzi, Massimo" sort="Provenzi, Massimo" uniqKey="Provenzi M" first="Massimo" last="Provenzi">Massimo Provenzi</name><affiliation wicri:level="1"><nlm:aff id="aff5">Oncologia Pediatrica, Ospedale Papa Giovanni XXIII, Bergamo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Oncologia Pediatrica, Ospedale Papa Giovanni XXIII, Bergamo</wicri:regionArea><wicri:noRegion>Bergamo</wicri:noRegion></affiliation></author><author><name sortKey="Rizzari, Carmelo" sort="Rizzari, Carmelo" uniqKey="Rizzari C" first="Carmelo" last="Rizzari">Carmelo Rizzari</name><affiliation><nlm:aff id="aff6">Pediatric Hematology Oncology Unit, Department of Pediatrics, University of Milano-Bicocca, MBBM Foundation, ASST Monza</nlm:aff><wicri:noCountry code="subfield">ASST Monza</wicri:noCountry></affiliation></author><author><name sortKey="Rives, Susana" sort="Rives, Susana" uniqKey="Rives S" first="Susana" last="Rives">Susana Rives</name><affiliation wicri:level="1"><nlm:aff id="aff7">Hospital Sant Joan de Déu de Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Sant Joan de Déu de Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Del Pozo Carlavilla, Maria" sort="Del Pozo Carlavilla, Maria" uniqKey="Del Pozo Carlavilla M" first="María" last="Del Pozo Carlavilla">María Del Pozo Carlavilla</name><affiliation wicri:level="1"><nlm:aff id="aff8">Hospital General Universitario de Albacete, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital General Universitario de Albacete</wicri:regionArea></affiliation></author><author><name sortKey="Valerio Alonso, Maria Eli" sort="Valerio Alonso, Maria Eli" uniqKey="Valerio Alonso M" first="Maria Eli" last="Valerio Alonso">Maria Eli Valerio Alonso</name><affiliation wicri:level="1"><nlm:aff id="aff8">Hospital General Universitario de Albacete, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital General Universitario de Albacete</wicri:regionArea></affiliation></author><author><name sortKey="Dominguez Pinilla, Nerea" sort="Dominguez Pinilla, Nerea" uniqKey="Dominguez Pinilla N" first="Nerea" last="Domínguez Pinilla">Nerea Domínguez Pinilla</name><affiliation wicri:level="1"><nlm:aff id="aff9">Hospital Virgen de la Salud, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Virgen de la Salud</wicri:regionArea></affiliation></author><author><name sortKey="Bourquin, Jean Pierre" sort="Bourquin, Jean Pierre" uniqKey="Bourquin J" first="Jean-Pierre" last="Bourquin">Jean-Pierre Bourquin</name><affiliation wicri:level="1"><nlm:aff id="aff10">Department of Oncology and Children’s Research Center, University Children’s Hospital Zurich, Zurich, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Oncology and Children’s Research Center, University Children’s Hospital Zurich, Zurich</wicri:regionArea><wicri:noRegion>Zurich</wicri:noRegion></affiliation></author><author><name sortKey="Schmiegelow, Kjeld" sort="Schmiegelow, Kjeld" uniqKey="Schmiegelow K" first="Kjeld" last="Schmiegelow">Kjeld Schmiegelow</name><affiliation wicri:level="3"><nlm:aff id="aff11">Department of Peadiatrics and Adolescent Medicine, Rigshospitalet University Hospital, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Peadiatrics and Adolescent Medicine, Rigshospitalet University Hospital, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Attarbaschi, Andishe" sort="Attarbaschi, Andishe" uniqKey="Attarbaschi A" first="Andishe" last="Attarbaschi">Andishe Attarbaschi</name><affiliation wicri:level="3"><nlm:aff id="aff12">Department of Pediatric Hematology and Oncology, St. Anna Children's Hospital, Medical University of Vienna, Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Pediatric Hematology and Oncology, St. Anna Children's Hospital, Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Grillner, Pernilla" sort="Grillner, Pernilla" uniqKey="Grillner P" first="Pernilla" last="Grillner">Pernilla Grillner</name><affiliation wicri:level="1"><nlm:aff id="aff13">Pediatric Oncology, Karolinska University Hospital, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Pediatric Oncology, Karolinska University Hospital</wicri:regionArea><wicri:noRegion>Karolinska University Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Mellgren, Karin" sort="Mellgren, Karin" uniqKey="Mellgren K" first="Karin" last="Mellgren">Karin Mellgren</name><affiliation wicri:level="1"><nlm:aff id="aff14">Department of Pediatric Haematology and Oncology, Sahlgrenska University Hospital, Gothenberg, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Pediatric Haematology and Oncology, Sahlgrenska University Hospital, Gothenberg</wicri:regionArea><wicri:noRegion>Gothenberg</wicri:noRegion></affiliation></author><author><name sortKey="Ten Bosch Van Der Werff, J" sort="Ten Bosch Van Der Werff, J" uniqKey="Ten Bosch Van Der Werff J" first="J." last="Ten Bosch Van Der Werff">J. Ten Bosch Van Der Werff</name><affiliation wicri:level="1"><nlm:aff id="aff15">UZ Brussels, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>UZ Brussels</wicri:regionArea></affiliation></author><author><name sortKey="Pieters, Rob" sort="Pieters, Rob" uniqKey="Pieters R" first="Rob" last="Pieters">Rob Pieters</name><affiliation wicri:level="3"><nlm:aff id="aff16">Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Princess Maxima Center for Pediatric Oncology, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Brozou, Triantafyllia" sort="Brozou, Triantafyllia" uniqKey="Brozou T" first="Triantafyllia" last="Brozou">Triantafyllia Brozou</name><affiliation><nlm:aff id="aff17">Department of Pediatric Oncology Hematology and Clinical Immunology Heinrich Heine University Dusseldorf</nlm:aff></affiliation></author><author><name sortKey="Borkhardt, Arndt" sort="Borkhardt, Arndt" uniqKey="Borkhardt A" first="Arndt" last="Borkhardt">Arndt Borkhardt</name><affiliation><nlm:aff id="aff17">Department of Pediatric Oncology Hematology and Clinical Immunology Heinrich Heine University Dusseldorf</nlm:aff></affiliation></author><author><name sortKey="Escherich, Gabriele" sort="Escherich, Gabriele" uniqKey="Escherich G" first="Gabriele" last="Escherich">Gabriele Escherich</name><affiliation wicri:level="3"><nlm:aff id="aff18">Klinik für Pädiatrische Hämatologie und Onkologie Universtitätsklinikum Eppendorf, Hamburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinik für Pädiatrische Hämatologie und Onkologie Universtitätsklinikum Eppendorf, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Lauten, Melchior" sort="Lauten, Melchior" uniqKey="Lauten M" first="Melchior" last="Lauten">Melchior Lauten</name><affiliation wicri:level="1"><nlm:aff id="aff19">University Hospital Schleswig-Holstein, Campus Lübeck, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Hospital Schleswig-Holstein, Campus Lübeck</wicri:regionArea><wicri:noRegion>Campus Lübeck</wicri:noRegion><wicri:noRegion>Campus Lübeck</wicri:noRegion><wicri:noRegion>Campus Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Stanulla, Martin" sort="Stanulla, Martin" uniqKey="Stanulla M" first="Martin" last="Stanulla">Martin Stanulla</name><affiliation wicri:level="3"><nlm:aff id="aff20">Department of Pediatric Haematology and Oncology, Hannover Medical School, Hannover, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pediatric Haematology and Oncology, Hannover Medical School, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Smith, Owen" sort="Smith, Owen" uniqKey="Smith O" first="Owen" last="Smith">Owen Smith</name><affiliation wicri:level="1"><nlm:aff id="aff21">National Children’s Cancer Service, Children’s Health Ireland at Crumlin, Dublin, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>National Children’s Cancer Service, Children’s Health Ireland at Crumlin, Dublin</wicri:regionArea><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Juh Yeoh, Allen Eng" sort="Juh Yeoh, Allen Eng" uniqKey="Juh Yeoh A" first="Allen Eng" last="Juh Yeoh">Allen Eng Juh Yeoh</name><affiliation wicri:level="4"><nlm:aff id="aff22">Yong Loo Lin School of Medicine and Cancer Science Institute, National University of Singapore, and Viva-University Children's Cancer Centre, National University Hospital, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Yong Loo Lin School of Medicine and Cancer Science Institute, National University of Singapore, and Viva-University Children's Cancer Centre, National University Hospital</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Elitzur, Sarah" sort="Elitzur, Sarah" uniqKey="Elitzur S" first="Sarah" last="Elitzur">Sarah Elitzur</name><affiliation><nlm:aff id="aff23">Schneider Children's Medical Center of Israel</nlm:aff></affiliation></author><author><name sortKey="Vora, Ajay" sort="Vora, Ajay" uniqKey="Vora A" first="Ajay" last="Vora">Ajay Vora</name><affiliation wicri:level="3"><nlm:aff id="aff24">Great Ormond Street Hospital, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Great Ormond Street Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Li, Chi Kong" sort="Li, Chi Kong" uniqKey="Li C" first="Chi-Kong" last="Li">Chi-Kong Li</name><affiliation wicri:level="4"><nlm:aff id="aff25">Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong</nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Ariffin, Hany" sort="Ariffin, Hany" uniqKey="Ariffin H" first="Hany" last="Ariffin">Hany Ariffin</name><affiliation wicri:level="1"><nlm:aff id="aff26">University of Malaya Medical Centre, Kuala Lumpur, Malaysia</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>University of Malaya Medical Centre, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Kolenova, Alexandra" sort="Kolenova, Alexandra" uniqKey="Kolenova A" first="Alexandra" last="Kolenova">Alexandra Kolenova</name><affiliation wicri:level="1"><nlm:aff id="aff27">Department of Pediatric Hematology and Oncology, Comenius University, Bratislava, Slovakia</nlm:aff><country xml:lang="fr">Slovaquie</country><wicri:regionArea>Department of Pediatric Hematology and Oncology, Comenius University, Bratislava</wicri:regionArea><wicri:noRegion>Bratislava</wicri:noRegion></affiliation></author><author><name sortKey="Dallapozza, Luciano" sort="Dallapozza, Luciano" uniqKey="Dallapozza L" first="Luciano" last="Dallapozza">Luciano Dallapozza</name><affiliation wicri:level="1"><nlm:aff id="aff28">The Cancer Centre for Children, The Children's Hospital at Westmead, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>The Cancer Centre for Children, The Children's Hospital at Westmead</wicri:regionArea><wicri:noRegion>The Children's Hospital at Westmead</wicri:noRegion></affiliation></author><author><name sortKey="Farah, Roula" sort="Farah, Roula" uniqKey="Farah R" first="Roula" last="Farah">Roula Farah</name><affiliation wicri:level="1"><nlm:aff id="aff29">LAUMC-Rizk Hospital, Beirut, Lebanon</nlm:aff><country xml:lang="fr">Liban</country><wicri:regionArea>LAUMC-Rizk Hospital, Beirut</wicri:regionArea><wicri:noRegion>Beirut</wicri:noRegion></affiliation></author><author><name sortKey="Lazic, Jelena" sort="Lazic, Jelena" uniqKey="Lazic J" first="Jelena" last="Lazic">Jelena Lazic</name><affiliation wicri:level="1"><nlm:aff id="aff30">University Children`s Hospital, Belgrade, Serbia</nlm:aff><country xml:lang="fr">Serbie</country><wicri:regionArea>University Children`s Hospital, Belgrade</wicri:regionArea><wicri:noRegion>Belgrade</wicri:noRegion></affiliation></author><author><name sortKey="Manabe, Atsushi" sort="Manabe, Atsushi" uniqKey="Manabe A" first="Atsushi" last="Manabe">Atsushi Manabe</name><affiliation wicri:level="1"><nlm:aff id="aff31">Hokkaido University in Sapporo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Hokkaido University in Sapporo</wicri:regionArea></affiliation></author><author><name sortKey="Styczynski, Jan" sort="Styczynski, Jan" uniqKey="Styczynski J" first="Jan" last="Styczynski">Jan Styczynski</name><affiliation wicri:level="1"><nlm:aff id="aff32">Department of Pediatric Hematology and Oncology, Nicolaus Copernicus University, Bydgoszcz, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Pediatric Hematology and Oncology, Nicolaus Copernicus University, Bydgoszcz</wicri:regionArea><wicri:noRegion>Bydgoszcz</wicri:noRegion></affiliation></author><author><name sortKey="Kovacs, Gabor" sort="Kovacs, Gabor" uniqKey="Kovacs G" first="Gabor" last="Kovacs">Gabor Kovacs</name><affiliation wicri:level="3"><nlm:aff id="aff33">2nd Department of Paediatrics, Semmelweis University, Budapest, Hungary</nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>2nd Department of Paediatrics, Semmelweis University, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Ottoffy, Gabor" sort="Ottoffy, Gabor" uniqKey="Ottoffy G" first="Gabor" last="Ottoffy">Gabor Ottoffy</name><affiliation wicri:level="1"><nlm:aff id="aff34">Oncohematology Unit, Dep. of Ped., University of Pécs, Hungary</nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>Oncohematology Unit, Dep. of Ped., University of Pécs</wicri:regionArea><wicri:noRegion>University of Pécs</wicri:noRegion></affiliation></author><author><name sortKey="Felice, Marisa" sort="Felice, Marisa" uniqKey="Felice M" first="Marisa" last="Felice">Marisa Felice</name><affiliation wicri:level="1"><nlm:aff id="aff35">Hospital de Pediatría, "Prof. Dr. Juan P. Garrahan", Argentina</nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea>Hospital de Pediatría, "Prof. Dr. Juan P. Garrahan"</wicri:regionArea><wicri:noRegion>"Prof. Dr. Juan P. Garrahan"</wicri:noRegion></affiliation></author><author><name sortKey="Buldini, Barbara" sort="Buldini, Barbara" uniqKey="Buldini B" first="Barbara" last="Buldini">Barbara Buldini</name><affiliation wicri:level="4"><nlm:aff id="aff36">Onco Hematology Unit, Dept. Salute della Donna e del Bambino, Università degli Studi di Padova, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Onco Hematology Unit, Dept. Salute della Donna e del Bambino, Università degli Studi di Padova</wicri:regionArea><placeName><settlement type="city">Padoue</settlement><region type="region" nuts="2">Vénétie</region></placeName><orgName type="university">Université de Padoue</orgName></affiliation></author><author><name sortKey="Conter, Valentino" sort="Conter, Valentino" uniqKey="Conter V" first="Valentino" last="Conter">Valentino Conter</name><affiliation wicri:level="1"><nlm:aff id="aff4">Clinica Pediatrica Universita degli Studi di Milano Bicocca, Monza, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Clinica Pediatrica Universita degli Studi di Milano Bicocca, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation></author><author><name sortKey="Stary, Jan" sort="Stary, Jan" uniqKey="Stary J" first="Jan" last="Stary">Jan Stary</name><affiliation><nlm:aff id="aff2">Department of Pediatric Hematology, Charles University and Univ. Hospital Motol, Prague, Czechia</nlm:aff><wicri:noCountry code="subfield">Czechia</wicri:noCountry></affiliation></author><author><name sortKey="Schrappe, Martin" sort="Schrappe, Martin" uniqKey="Schrappe M" first="Martin" last="Schrappe">Martin Schrappe</name><affiliation wicri:level="3"><nlm:aff id="aff37">Childrens Hospital Medical Center Schleswig-Holstein, Kiel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Childrens Hospital Medical Center Schleswig-Holstein, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author></analytic><series><title level="j">European Journal of Cancer</title><idno type="ISSN">0959-8049</idno><idno type="eISSN">1879-0852</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Introduction</title><p>Since the beginning of COVID-19 pandemics, it is known that the severe course of the disease occurs mostly among elderly, whereas it is rare among children and young adults. Comorbidities, in particular diabetes and hypertension, clearly associated with age, besides obesity and smoke are strongly associated with the need of intensive treatment and a dismal outcome. A weaker immunity of the elderly has been proposed as a possible explanation of this uneven age distribution. Along the same line, anecdotal information from Wuhan, China mentioned a severe course of COVID-19 in a child treated for leukemia.</p></sec><sec><title>Aim and methods</title><p>We made a flash survey on COVID19 incidence and severity among children on anticancer treatment. Respondents were asked by email to fill in a short web based survey.</p></sec><sec><title>Results</title><p>We received reports from 25 countries, where approximately 10,000 patients at risk are followed. At the time of the survey, over 200 of these children were tested, nine of whom were positive for COVID-19. Eight of the nine cases had asymptomatic to mild disease and one was just diagnosed with COVID-19. We also discuss preventive measures that are in place or should be taken as well as treatment options in immunocompromised children with COVID-19.</p></sec><sec><title>Conclusion</title><p>Thus, even children receiving anti-cancer chemotherapy may have a mild or asymptomatic course of COVID-19. While we should not underestimate the risk of developing a more severe course of COVID-19 than observed here, the intensity of preventive measures should not cause delays or obstructions in oncological treatment.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Wu, Z" uniqKey="Wu Z">Z. Wu</name></author><author><name sortKey="Mcgoogan, J M" uniqKey="Mcgoogan J">J.M. McGoogan</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Lu, X" uniqKey="Lu X">X. Lu</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L. Zhang</name></author><author><name sortKey="Du, H" uniqKey="Du H">H. Du</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wei, M" uniqKey="Wei M">M. Wei</name></author><author><name sortKey="Yuan, J" uniqKey="Yuan J">J. Yuan</name></author><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y. Liu</name></author><author><name sortKey="Fu, T" uniqKey="Fu T">T. Fu</name></author><author><name sortKey="Yu, X" uniqKey="Yu X">X. Yu</name></author><author><name sortKey="Zhang, Z J" uniqKey="Zhang Z">Z.-J. Zhang</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Liu, W" uniqKey="Liu W">W. Liu</name></author><author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q. Zhang</name></author><author><name sortKey="Chen, J" uniqKey="Chen J">J. Chen</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Z" uniqKey="Chen Z">Z. Chen</name></author><author><name sortKey="Xiong, H" uniqKey="Xiong H">H. Xiong</name></author><author><name sortKey="Li, J X" uniqKey="Li J">J.X. Li</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Ogimi, C" uniqKey="Ogimi C">C. Ogimi</name></author><author><name sortKey="Englund, J A" uniqKey="Englund J">J.A. Englund</name></author><author><name sortKey="Bradford, M C" uniqKey="Bradford M">M.C. Bradford</name></author><author><name sortKey="Qin, X" uniqKey="Qin X">X. Qin</name></author><author><name sortKey="Boeckh, M" uniqKey="Boeckh M">M. Boeckh</name></author><author><name sortKey="Waghmare, A" uniqKey="Waghmare A">A. Waghmare</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Janka, G E" uniqKey="Janka G">G.E. Janka</name></author><author><name sortKey="Lehmberg, K" uniqKey="Lehmberg K">K. Lehmberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, C K" uniqKey="Li C">C.K. Li</name></author><author><name sortKey="Zee, B" uniqKey="Zee B">B. Zee</name></author><author><name sortKey="Lee, J" uniqKey="Lee J">J. Lee</name></author><author><name sortKey="Chik, K W" uniqKey="Chik K">K.W. Chik</name></author><author><name sortKey="Ha, S Y" uniqKey="Ha S">S.Y. Ha</name></author><author><name sortKey="Lee, V" uniqKey="Lee V">V. Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Klein, K" uniqKey="Klein K">K. Klein</name></author><author><name sortKey="Hasle, H" uniqKey="Hasle H">H. Hasle</name></author><author><name sortKey="Abrahamsson, J" uniqKey="Abrahamsson J">J. Abrahamsson</name></author><author><name sortKey="De Moerloose, B" uniqKey="De Moerloose B">B. De Moerloose</name></author><author><name sortKey="Kaspers, G J L" uniqKey="Kaspers G">G.J.L. Kaspers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shachor Meyouhas, Y" uniqKey="Shachor Meyouhas Y">Y. Shachor-Meyouhas</name></author><author><name sortKey="Zaidman, I" uniqKey="Zaidman I">I. Zaidman</name></author><author><name sortKey="Kra Oz, Z" uniqKey="Kra Oz Z">Z. Kra-Oz</name></author><author><name sortKey="Arad Cohen, N" uniqKey="Arad Cohen N">N. Arad-Cohen</name></author><author><name sortKey="Kassis, I" uniqKey="Kassis I">I. Kassis</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Argentine</li><li>Australie</li><li>Autriche</li><li>Belgique</li><li>Danemark</li><li>Espagne</li><li>Hong Kong</li><li>Hongrie</li><li>Irlande (pays)</li><li>Italie</li><li>Japon</li><li>Liban</li><li>Malaisie</li><li>Pays-Bas</li><li>Pologne</li><li>Royaume-Uni</li><li>Serbie</li><li>Singapour</li><li>Slovaquie</li><li>Suisse</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Basse-Saxe</li><li>Grand Londres</li><li>Hambourg</li><li>Hongrie centrale</li><li>Hovedstaden</li><li>Schleswig-Holstein</li><li>Tennessee</li><li>Utrecht (province)</li><li>Vienne (Autriche)</li><li>Vénétie</li></region><settlement><li>Budapest</li><li>Copenhague</li><li>Hambourg</li><li>Hanovre</li><li>Kiel</li><li>Londres</li><li>Padoue</li><li>Sha Tin</li><li>Utrecht</li><li>Vienne (Autriche)</li></settlement><orgName><li>Université chinoise de Hong Kong</li><li>Université de Padoue</li><li>Université nationale de Singapour</li></orgName></list><tree><noCountry><name sortKey="Borkhardt, Arndt" sort="Borkhardt, Arndt" uniqKey="Borkhardt A" first="Arndt" last="Borkhardt">Arndt Borkhardt</name><name sortKey="Brozou, Triantafyllia" sort="Brozou, Triantafyllia" uniqKey="Brozou T" first="Triantafyllia" last="Brozou">Triantafyllia Brozou</name><name sortKey="Elitzur, Sarah" sort="Elitzur, Sarah" uniqKey="Elitzur S" first="Sarah" last="Elitzur">Sarah Elitzur</name><name sortKey="Hrusak, Ondrej" sort="Hrusak, Ondrej" uniqKey="Hrusak O" first="Ondrej" last="Hrusak">Ondrej Hrusak</name><name sortKey="Kalina, Tomas" sort="Kalina, Tomas" uniqKey="Kalina T" first="Tomas" last="Kalina">Tomas Kalina</name><name sortKey="Rizzari, Carmelo" sort="Rizzari, Carmelo" uniqKey="Rizzari C" first="Carmelo" last="Rizzari">Carmelo Rizzari</name><name sortKey="Stary, Jan" sort="Stary, Jan" uniqKey="Stary J" first="Jan" last="Stary">Jan Stary</name></noCountry><country name="États-Unis"><region name="Tennessee"><name sortKey="Wolf, Joshua" sort="Wolf, Joshua" uniqKey="Wolf J" first="Joshua" last="Wolf">Joshua Wolf</name></region></country><country name="Italie"><noRegion><name sortKey="Balduzzi, Adriana" sort="Balduzzi, Adriana" uniqKey="Balduzzi A" first="Adriana" last="Balduzzi">Adriana Balduzzi</name></noRegion><name sortKey="Buldini, Barbara" sort="Buldini, Barbara" uniqKey="Buldini B" first="Barbara" last="Buldini">Barbara Buldini</name><name sortKey="Conter, Valentino" sort="Conter, Valentino" uniqKey="Conter V" first="Valentino" last="Conter">Valentino Conter</name><name sortKey="Provenzi, Massimo" sort="Provenzi, Massimo" uniqKey="Provenzi M" first="Massimo" last="Provenzi">Massimo Provenzi</name></country><country name="Espagne"><noRegion><name sortKey="Rives, Susana" sort="Rives, Susana" uniqKey="Rives S" first="Susana" last="Rives">Susana Rives</name></noRegion><name sortKey="Del Pozo Carlavilla, Maria" sort="Del Pozo Carlavilla, Maria" uniqKey="Del Pozo Carlavilla M" first="María" last="Del Pozo Carlavilla">María Del Pozo Carlavilla</name><name sortKey="Dominguez Pinilla, Nerea" sort="Dominguez Pinilla, Nerea" uniqKey="Dominguez Pinilla N" first="Nerea" last="Domínguez Pinilla">Nerea Domínguez Pinilla</name><name sortKey="Valerio Alonso, Maria Eli" sort="Valerio Alonso, Maria Eli" uniqKey="Valerio Alonso M" first="Maria Eli" last="Valerio Alonso">Maria Eli Valerio Alonso</name></country><country name="Suisse"><noRegion><name sortKey="Bourquin, Jean Pierre" sort="Bourquin, Jean Pierre" uniqKey="Bourquin J" first="Jean-Pierre" last="Bourquin">Jean-Pierre Bourquin</name></noRegion></country><country name="Danemark"><region name="Hovedstaden"><name sortKey="Schmiegelow, Kjeld" sort="Schmiegelow, Kjeld" uniqKey="Schmiegelow K" first="Kjeld" last="Schmiegelow">Kjeld Schmiegelow</name></region></country><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Attarbaschi, Andishe" sort="Attarbaschi, Andishe" uniqKey="Attarbaschi A" first="Andishe" last="Attarbaschi">Andishe Attarbaschi</name></region></country><country name="Suède"><noRegion><name sortKey="Grillner, Pernilla" sort="Grillner, Pernilla" uniqKey="Grillner P" first="Pernilla" last="Grillner">Pernilla Grillner</name></noRegion><name sortKey="Mellgren, Karin" sort="Mellgren, Karin" uniqKey="Mellgren K" first="Karin" last="Mellgren">Karin Mellgren</name></country><country name="Belgique"><noRegion><name sortKey="Ten Bosch Van Der Werff, J" sort="Ten Bosch Van Der Werff, J" uniqKey="Ten Bosch Van Der Werff J" first="J." last="Ten Bosch Van Der Werff">J. Ten Bosch Van Der Werff</name></noRegion></country><country name="Pays-Bas"><region name="Utrecht (province)"><name sortKey="Pieters, Rob" sort="Pieters, Rob" uniqKey="Pieters R" first="Rob" last="Pieters">Rob Pieters</name></region></country><country name="Allemagne"><region name="Hambourg"><name sortKey="Escherich, Gabriele" sort="Escherich, Gabriele" uniqKey="Escherich G" first="Gabriele" last="Escherich">Gabriele Escherich</name></region><name sortKey="Lauten, Melchior" sort="Lauten, Melchior" uniqKey="Lauten M" first="Melchior" last="Lauten">Melchior Lauten</name><name sortKey="Schrappe, Martin" sort="Schrappe, Martin" uniqKey="Schrappe M" first="Martin" last="Schrappe">Martin Schrappe</name><name sortKey="Stanulla, Martin" sort="Stanulla, Martin" uniqKey="Stanulla M" first="Martin" last="Stanulla">Martin Stanulla</name></country><country name="Irlande (pays)"><noRegion><name sortKey="Smith, Owen" sort="Smith, Owen" uniqKey="Smith O" first="Owen" last="Smith">Owen Smith</name></noRegion></country><country name="Singapour"><noRegion><name sortKey="Juh Yeoh, Allen Eng" sort="Juh Yeoh, Allen Eng" uniqKey="Juh Yeoh A" first="Allen Eng" last="Juh Yeoh">Allen Eng Juh Yeoh</name></noRegion></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Vora, Ajay" sort="Vora, Ajay" uniqKey="Vora A" first="Ajay" last="Vora">Ajay Vora</name></region></country><country name="Hong Kong"><noRegion><name sortKey="Li, Chi Kong" sort="Li, Chi Kong" uniqKey="Li C" first="Chi-Kong" last="Li">Chi-Kong Li</name></noRegion></country><country name="Malaisie"><noRegion><name sortKey="Ariffin, Hany" sort="Ariffin, Hany" uniqKey="Ariffin H" first="Hany" last="Ariffin">Hany Ariffin</name></noRegion></country><country name="Slovaquie"><noRegion><name sortKey="Kolenova, Alexandra" sort="Kolenova, Alexandra" uniqKey="Kolenova A" first="Alexandra" last="Kolenova">Alexandra Kolenova</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Dallapozza, Luciano" sort="Dallapozza, Luciano" uniqKey="Dallapozza L" first="Luciano" last="Dallapozza">Luciano Dallapozza</name></noRegion></country><country name="Liban"><noRegion><name sortKey="Farah, Roula" sort="Farah, Roula" uniqKey="Farah R" first="Roula" last="Farah">Roula Farah</name></noRegion></country><country name="Serbie"><noRegion><name sortKey="Lazic, Jelena" sort="Lazic, Jelena" uniqKey="Lazic J" first="Jelena" last="Lazic">Jelena Lazic</name></noRegion></country><country name="Japon"><noRegion><name sortKey="Manabe, Atsushi" sort="Manabe, Atsushi" uniqKey="Manabe A" first="Atsushi" last="Manabe">Atsushi Manabe</name></noRegion></country><country name="Pologne"><noRegion><name sortKey="Styczynski, Jan" sort="Styczynski, Jan" uniqKey="Styczynski J" first="Jan" last="Styczynski">Jan Styczynski</name></noRegion></country><country name="Hongrie"><region name="Hongrie centrale"><name sortKey="Kovacs, Gabor" sort="Kovacs, Gabor" uniqKey="Kovacs G" first="Gabor" last="Kovacs">Gabor Kovacs</name></region><name sortKey="Ottoffy, Gabor" sort="Ottoffy, Gabor" uniqKey="Ottoffy G" first="Gabor" last="Ottoffy">Gabor Ottoffy</name></country><country name="Argentine"><noRegion><name sortKey="Felice, Marisa" sort="Felice, Marisa" uniqKey="Felice M" first="Marisa" last="Felice">Marisa Felice</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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